Vallone Lab
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RESEARCH

The Vallone Lab works in structural biology to understand the structure-function relationship of proteins and protein complexes. We apply this knowledge to engineer proteins for theranostics and to adapt enzymes for biotechnology.
We also aim at understanding the physiological and pathological role of proteins such as neuroglobin, kinases and receptors.
The Vallone lab adopts an integrated structural biology approach using X-ray crystallography, X-ray scattering and cryo-electron microscopy to obtain a full and dynamic pictures of proteins in action.
The current research lines include large dynamic complexes between plasma proteins and their receptors, neuroglobin and P450 cytochromes involved in antibiotic biosynthesis.
We analyse protein function and dynamics using a wide range of biochemical methods including kinetics and classic and advanced spectroscopy.

Research Lines

Ferritin - Transferrin Receptor

Ferritin / Transferrin Receptor

OleP‐6DEB complex. A) Superposition of the open (green) and closed (wheat) conformations of OleP‐6DEB complex

P450

Cavities in NgbCO (blue) and unligated metNgb (yellow) as determined by using surfnet (46). The position of Ser-55 is highlighted in green.

Globins

Fluorescence of human SRD5As and TECR

Membrane Proteins and Drug Design

Kinases and Targeted Therapy

Fungal enzymes and cellulose degradation

Grants

PROMETEUS-RISE Protein and Membrane Technology Consortium

X-PROBE Innovative Training Network

Links (A-Z)

Scientific societies

AIC | Associazione Italiana Cristallografia
AIC | Section on Biological Macromolecules (BMM)
International Union of Crystallography
International Union of Crystallography - Commission on Biological Macromolecules
SIB | Società Italiana di Biochimica e Biologia Molecolare
SIB | Protein Group Newsletter
SILS | Società Italiana Luce di Sincrotrone

Synchrotrons

Diamond
ELETRA | Sincrotrone Trieste
ESRF | European Synchrotron Radiation Facility

Infrastructures

CRC Pediatrica | Gruppo Bolognesi
Instruct Eric
Instruct - ITALIA

Teaching

CLMMC "F"
C.L.M. in Medicina e Chirurgia "A"
International School of Crystallography

Collaborating labs & companies

Mancia Lab | Columbia University
Prometeus RISE MSCA Action
Protein Design Laboratory at Yokohama City University
Sapienza Innovazione

Institutions

Dipartimento di Scienze Biochimiche "A. Rossi Fanelli"
H2CU | Honors Center of Italian Universities
IBPM | Istituto di Biologia e Patologia Molecolari
The Italian Academy NYC

Friends

Willa Appel
Francesca Bartolini
Bruno Botta
Francesca Cutruzzolà
Ben F. Luisi
Anna Moroni
Marie-Claude Potier
Daniela Rhodes
Isabella Saggio
Lawrence S. Shapiro
Gebhard F.X. Schertler
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© Copyright – Beatrice Vallone – Webdesign Fabio Baldanello – Cookies Policy – Privacy Policy

© Copyright – Beatrice Vallone
Webdesign Fabio Baldanello
Cookies Policy – Privacy Policy

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