The Vallone Lab works in structural biology to understand the structure-function relationship of proteins and protein complexes. We apply this knowledge to engineer proteins for theranostics and to adapt enzymes for biotechnology.
We also aim at understanding the physiological and pathological role of proteins such as neuroglobin, kinases and receptors.
The Vallone lab adopts an integrated structural biology approach using X-ray crystallography, X-ray scattering and cryo-electron microscopy to obtain a full and dynamic pictures of proteins in action.
The current research lines include large dynamic complexes between plasma proteins and their receptors, neuroglobin and P450 cytochromes involved in antibiotic biosynthesis.
We analyse protein function and dynamics using a wide range of biochemical methods including kinetics and classic and advanced spectroscopy.