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Ferritin / Transferrin Receptor

Ferritin – Transferrin Receptor

Structure of the human CD71 H-Ft complex

CD71 receptor- ligand recognition epitopes and binding modes

We are working in collaboration with Prof. Boffi in the production of engineered ferritins as nanocarriers for therapy and diagnostics. In order to better target modified ferritins to cells expressing the transferrin CD71 receptor we determined by CryoEM the structure of the Ferritin/CD71 complex.

Unsing CryoEM are expanding this study to engineered archeal ferritins and we are pursuing the structure and the chemical and biochemical enginering of other plasma proteins to design fully biocompatible nanotools and nanocarriers, in complex with their receptors.

Main Publications

Cryo-EM structure of the human ferritin-transferrin receptor 1 complex.
Montemiglio LC, Testi C, Ceci P, Falvo E, Pitea M, Savino C, Arcovito A, Peruzzi G, Baiocco P, Mancia F, Boffi A, des Georges A, Vallone B.
Nature Communications 2019 Mar 8;10(1):1121. doi: 10.1038/s41467-019-09098-w.
PMID:30850661
Free PMC Article

Humanized archaeal ferritin as a tool for cell targeted delivery.
de Turris V, Cardoso Trabuco M, Peruzzi G, Boffi A, Testi C, Vallone B, Celeste Montemiglio L, Georges AD, Calisti L, Benni I, Bonamore A, Baiocco P.
Nanoscale. 2017 Jan 5;9(2):647-655. doi: 10.1039/c6nr07129e.

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All/Grants/Research Lines
Ferritin - Transferrin Receptor
April 1, 2020

Ferritin / Transferrin Receptor

OleP‐6DEB complex. A) Superposition of the open (green) and closed (wheat) conformations of OleP‐6DEB complex
April 1, 2020

P450

Cavities in NgbCO (blue) and unligated metNgb (yellow) as determined by using surfnet (46). The position of Ser-55 is highlighted in green.
April 1, 2020

Globins

Fluorescence of human SRD5As and TECR
March 28, 2020

Membrane Proteins and Drug Design

March 28, 2020

Kinases and Targeted Therapy

March 28, 2020

Fungal enzymes and cellulose degradation

March 27, 2020

PROMETEUS-RISE Protein and Membrane Technology Consortium

March 27, 2020

X-PROBE Innovative Training Network

March 27, 2020

PROMETEUS-RISE Protein and Membrane Technology Consortium

March 27, 2020

X-PROBE Innovative Training Network

Ferritin - Transferrin Receptor
April 1, 2020

Ferritin / Transferrin Receptor

OleP‐6DEB complex. A) Superposition of the open (green) and closed (wheat) conformations of OleP‐6DEB complex
April 1, 2020

P450

Cavities in NgbCO (blue) and unligated metNgb (yellow) as determined by using surfnet (46). The position of Ser-55 is highlighted in green.
April 1, 2020

Globins

Fluorescence of human SRD5As and TECR
March 28, 2020

Membrane Proteins and Drug Design

March 28, 2020

Kinases and Targeted Therapy

March 28, 2020

Fungal enzymes and cellulose degradation

 
 
 

© Copyright – Beatrice Vallone – Webdesign Fabio Baldanello – Cookies Policy – Privacy Policy

© Copyright – Beatrice Vallone
Webdesign Fabio Baldanello
Cookies Policy – Privacy Policy

Link to: P450 Link to: P450 P450OleP‐6DEB complex. A) Superposition of the open (green) and closed (wheat) conformations of OleP‐6DEB complex
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