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Membrane Proteins and Drug Design

Schematic cartoon and expression of human SRD5As TECR and TECRL eGFP fusion proteins

Fluorescence of human SRD5As and TECR

TECRL proteins in relation to endogenous ERp57

A collaboration with Filippo Mancia from Columbia University is poised to determine the structure of membrane enzymes crucial for drug design and the understanding of pathologies linked to metabolite transport and transformation.

A multinational and multidisciplinary effort suppoted by a MSCA RISE action, Prometeus-Rise Protein and Membrane Technology Consortium (https://prometeus-rise.org/), is coordinated by the Vallone Lab.

Main Publications

Subcellular localization of the five members of the human steroid 5α-reductase family.
Scaglione A, Montemiglio LC, Parisi G, Asteriti IA, Bruni R, Cerutti G, Testi C, Savino C, Mancia F, Lavia P, Vallone B.
Biochim Open. 2017 Jun;4:99-106. doi: 10.1016/j.biopen.2017.03.003. Epub 2017 Mar 21.
PMID: 29082129
Free PMC Article

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All/Grants/Research Lines
Ferritin - Transferrin Receptor
April 1, 2020

Ferritin / Transferrin Receptor

OleP‐6DEB complex. A) Superposition of the open (green) and closed (wheat) conformations of OleP‐6DEB complex
April 1, 2020

P450

Cavities in NgbCO (blue) and unligated metNgb (yellow) as determined by using surfnet (46). The position of Ser-55 is highlighted in green.
April 1, 2020

Globins

Fluorescence of human SRD5As and TECR
March 28, 2020

Membrane Proteins and Drug Design

March 28, 2020

Kinases and Targeted Therapy

March 28, 2020

Fungal enzymes and cellulose degradation

March 27, 2020

PROMETEUS-RISE Protein and Membrane Technology Consortium

March 27, 2020

X-PROBE Innovative Training Network

March 27, 2020

PROMETEUS-RISE Protein and Membrane Technology Consortium

March 27, 2020

X-PROBE Innovative Training Network

Ferritin - Transferrin Receptor
April 1, 2020

Ferritin / Transferrin Receptor

OleP‐6DEB complex. A) Superposition of the open (green) and closed (wheat) conformations of OleP‐6DEB complex
April 1, 2020

P450

Cavities in NgbCO (blue) and unligated metNgb (yellow) as determined by using surfnet (46). The position of Ser-55 is highlighted in green.
April 1, 2020

Globins

Fluorescence of human SRD5As and TECR
March 28, 2020

Membrane Proteins and Drug Design

March 28, 2020

Kinases and Targeted Therapy

March 28, 2020

Fungal enzymes and cellulose degradation

 
 
 

© Copyright – Beatrice Vallone – Webdesign Fabio Baldanello – Cookies Policy – Privacy Policy

© Copyright – Beatrice Vallone
Webdesign Fabio Baldanello
Cookies Policy – Privacy Policy

Link to: Kinases and Targeted Therapy Link to: Kinases and Targeted Therapy Kinases and Targeted Therapy Link to: Globins Link to: Globins Cavities in NgbCO (blue) and unligated metNgb (yellow) as determined by using surfnet (46). The position of Ser-55 is highlighted in green.Globins
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